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Effect of a nutritional supplementation on bone health in Chilean elderly subjects with femoral osteoporosis.
Bunout, Daniel; Barrera, Gladys; Leiva, Laura; Gattas, Vivien; de la Maza, María Pía; Haschke, Ferdinand; Steenhout, Philippe; Klassen, Petra; Hager, Corinne; Offord, Elizabeth; Hirsch, Sandra.
Afiliação
  • Bunout D; INTA, Department of Medicine, Central Campus Facultyof Medicine, University of Chile, Santiago, CHILE. dbunout@inta.cl
J Am Coll Nutr ; 25(3): 170-7, 2006 Jun.
Article em En | MEDLINE | ID: mdl-16766774
OBJECTIVE: To study the effects of a special nutritional supplement on bone mineral density and bone turnover markers in Chilean elderly subjects with femoral osteoporosis. SETTING: Public primary health care clinics in Chile. SUBJECTS: Free living elderly subjects with femoral osteoporosis. INTERVENTIONS: Subjects were randomized to receive the usual nutritional supplement provided by the Chilean Ministry of Health or a special nutritional supplement providing, among other nutrients, 90 mg isoflavones, 800 mg calcium, 400 IU vitamin D, 60 ug vitamin K and 31 g proteins per day. MEASURES OF OUTCOME: At baseline, and after six and twelve months of supplementation, body composition, bone mineral density, serum 25 OH vitamin D, intact parathyroid hormone (iPTH), osteocalcin, decarboxylated osteocalcin, urinary aminoterminal telopeptide of type I collagen (NTX), deoxypyridoline cross links (Dpd) and equol were measured. Every month, urinary daidzein was measured in a morning urine sample. RESULTS: No differences between treatment groups were observed in body composition or bone mineral density changes. The group receiving the special supplement had a significant increase in serum 25 OH vitamin D and a significant decrease in serum iPTH and decarboxylated osteocalcin. No association between daidzein or equol excretion and changes in bone mineralization was observed. CONCLUSIONS: A special supplement delivered to elderly subjects with osteoporosis improved serum vitamin D and reduced serum iPTH and undercarboxylated osteocalcin levels but did not affect BMD.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Osso e Ossos / Densidade Óssea / Conservadores da Densidade Óssea Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: J Am Coll Nutr Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoporose / Osso e Ossos / Densidade Óssea / Conservadores da Densidade Óssea Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País/Região como assunto: America do sul / Chile Idioma: En Revista: J Am Coll Nutr Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Chile País de publicação: Estados Unidos