Immunohistochemical analysis of subcortical white matter astroglia of infant and adult primate brains, with a note on resident neurons.
Brain Res
; 1100(1): 93-103, 2006 Jul 19.
Article
em En
| MEDLINE
| ID: mdl-16765327
An immunohistochemical analysis of brain subcortical white matter astroglia from human (infant, adult) and adult monkey (Cebus apella, Macaca nemestrina) cases without any known neurological disease, is described. Expression of synaptic vesicle-associated proteins, excitatory amino acid transporters (EAAT1 and EAAT2) and GABAA Ralpha2 receptor produced coarse punctate labeling in human adult white matter astrocytes. A finer, generalized, punctate labeling was observed in human infants and adult C. apella monkeys. Labeling of neuronal somata and processes with microtubule-associated proteins (MAP2a-c) and neuron nuclear (NeuN) antibodies, was also observed in subcortical white matter of humans and monkeys. Results suggest competence of subcortical white matter astroglia of the primate brain to participate in various transmitter regulatory pathways. It is also proposed that, collectively with resident neurons, they may exert some role in affecting the transfer of information that takes place through the various associational and projecting fiber systems coursing through this brain compartment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Primatas
/
Encéfalo
/
Astrócitos
/
Neurônios
Limite:
Aged
/
Animals
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Humans
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Holanda