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[Origin and development of B1 lymphocytes. A cell population involved in defence and autoimmunity]. / Origen y desarrollo de linfocitos B1 una población celular involucrada en defensa y autoinmunidad.
Merino, Maria C; Gruppi, Adriana.
Afiliação
  • Merino MC; Departamento de Bioquímica Clínica-CIBICI, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba.
Medicina (B Aires) ; 66(2): 165-72, 2006.
Article em Es | MEDLINE | ID: mdl-16715770
B1 lymphocytes are an anatomically, phenotypically, and functionally distinct subset of B cells producing the bulk of natural serum IgM in the absence of any apparent stimulation by specific antigens. These cells are a dominant population of B cells in peritoneal and pleural cavities and they have characteristics of activated cells and higher cell size and cytoplasmic complexity than conventional B cells. B1 cells spontaneously secrete antibodies and operate under a differentiation program that is unique and differs from the paradigm associated with Ig-secreting B-2 cells. The antibodies produced by B1 cells may participate in a variety of physiological activities since they are involve in immune regulation, clearance of senescent and apoptotic cells and resistance to infection. However, it has been suggested that they are also involved in autoimmunity. Many advances have been made to describe the origin, development and differentiation of B1 cells, which will be examined here.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Autoimunidade Limite: Animals / Humans Idioma: Es Revista: Medicina (B Aires) Ano de publicação: 2006 Tipo de documento: Article País de publicação: Argentina
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Autoimunidade Limite: Animals / Humans Idioma: Es Revista: Medicina (B Aires) Ano de publicação: 2006 Tipo de documento: Article País de publicação: Argentina