Inhibition of antibody producing cells (PFC) from Peyer patches by glycoproteins from Entamoeba histolytica.
Rev Latinoam Microbiol
; 33(2-3): 165-70, 1991.
Article
em En
| MEDLINE
| ID: mdl-1670482
It is well known that Entamoeba histolytica can cause damage to its host by means of enzymes, cytotoxins and perforins that affect different types of cells. In this work we investigated the effect of different Entamoeba histolytica trophozoites products over the secretion of antibodies by mice Peyer's patches using a reverse hemolytic assay. Results showed that amoebic glycoproteins inhibited the secretion of antibodies by lymphocytes from mice Peyer's patches. In all cases the decrease in antibody secretion was not due to cell death. The molecules responsible for this effect were shown to be high molecular weight immunogenic glycoproteins without enzymatic activity. The fact that amoebic glycoproteins interfere with plasmatic cells function could be another mechanism of evasion of the immune response by Entamoeba histolytica, although we still do not know how these amoebic products cause the inhibition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nódulos Linfáticos Agregados
/
Glicoproteínas
/
Proteínas de Protozoários
/
Entamoeba histolytica
/
Células Produtoras de Anticorpos
Limite:
Animals
Idioma:
En
Revista:
Rev Latinoam Microbiol
Ano de publicação:
1991
Tipo de documento:
Article
País de publicação:
México