Association of paradoxical sleep deprivation and ecstasy (MDMA) enhances genital reflexes in male rats.
Behav Brain Res
; 170(2): 287-92, 2006 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-16621058
Ecstasy ((+/-)3,4-methylenedioxymethamphetamine, MDMA) is a psychostimulant and a synthetic derivative of amphetamine that, according to its consumers, promotes the enhancement of sexual pleasure. This study sought to investigate the effects of ecstasy in the genital reflexes of paradoxical sleep deprived (PSD) male rats. Distinct groups of PSD rats were administered with saline or different doses of ecstasy. The incidence of genital reflexes was verified for 100 min. The four doses that were used induced genital reflexes in PSD animals and these significantly differed from their respective treated control groups. Under the influence of two intermediary doses (2.5 and 5mg/kg), all animals displayed erection and ejaculation. The frequency of genital reflexes was also significantly greater than in relation to the PSD-saline group. The comparison between cocaine and ecstasy in PSD rats revealed that ecstasy induced more erections and ejaculations than cocaine. Thus, the present results showed a great enhancement of the genital reflexes of PSD rats that might have occurred due to serotoninergic alterations induced by this illicit substance when associated to sleep deprivation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Privação do Sono
/
Sono REM
/
Ereção Peniana
/
N-Metil-3,4-Metilenodioxianfetamina
/
Inibidores da Captação Adrenérgica
/
Ejaculação
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda