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Adaptations against heme toxicity in blood-feeding arthropods.
Graça-Souza, Aurélio V; Maya-Monteiro, Clarissa; Paiva-Silva, Gabriela O; Braz, Glória R C; Paes, Márcia C; Sorgine, Marcos H F; Oliveira, Marcus F; Oliveira, Pedro L.
Afiliação
  • Graça-Souza AV; Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Av. Brigadeiro Trompowsky, s/n, Cidade Universitária, Ilha do Fundão, 21941-690 Rio de Janeiro, RJ, Brazil.
Insect Biochem Mol Biol ; 36(4): 322-35, 2006 Apr.
Article em En | MEDLINE | ID: mdl-16551546
A blood-sucking habit appeared independently several times in the course of arthropod evolution. However, from more than a million species of insects and arachnids presently living on earth, only about 14,000 species developed the capacity to feed on vertebrate blood. This figure suggests the existence of severe physiological constraints for the evolution of hematophagy, implying the selective advantage of special adaptations related to the use of blood as a food source. Digestion of vertebrate hemoglobin in the midgut of blood-feeding arthropods results in the production of large amounts of heme, a potentially cytotoxic molecule. Here we will review mechanisms by which heme can exert biological damage, together with a wide spectrum of adaptations developed by blood-feeding insects and ticks to counteract its deleterious effects. In spite of the existence of a great molecular diversity of protective mechanisms, different hematophagous organisms developed convergent solutions that may be physiologically equivalent.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrópodes / Adaptação Fisiológica / Heme Limite: Animals Idioma: En Revista: Insect Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrópodes / Adaptação Fisiológica / Heme Limite: Animals Idioma: En Revista: Insect Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido