[Radioiodine therapy for differentiated thyroid carcinoma: methods used to increase the radiation absorbed dose]. / Tratamento do carcinoma diferenciado da tireóide com iodo-131: intervenções para aumentar a dose absorvida de radiação.
Arq Bras Endocrinol Metabol
; 49(3): 341-9, 2005 Jun.
Article
em Pt
| MEDLINE
| ID: mdl-16543987
OBJECTIVES: Our aim was to analyze measures taken to increase the radiation absorbed dose (DOSE) during treatment of well-differentiated thyroid cancer (DTC) with iodine-131. METHODS: An increase in DOSE is achieved by: avoiding competition with non-radioactive iodine, stimulating cellular uptake/retention, increasing the administered activity. Basis and results of each one of these methods were reviewed. RESULTS: Although it is difficult to demonstrate an increase in survival, there is a direct relation between DOSE and tumoral response in DTC. Different approaches can be used aiming an increase in DOSE, with a possible improvement in tumoral response for treatment with iodine-131. Although DTC is a relatively benign disease, a better response to treatment is highly desirable in high-risk patients, who have few other options of therapy. CONCLUSIONS: An increase in DOSE during treatment of DTC can be achieved using the described interventions, which should be used in high-risk cases of DTC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Radioisótopos do Iodo
Limite:
Humans
Idioma:
Pt
Revista:
Arq Bras Endocrinol Metabol
Ano de publicação:
2005
Tipo de documento:
Article
País de publicação:
Brasil