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[Outcome of acute lymphoblastic leukemia in the pediatric age group over a 29-year period (1972-2000)]. / Evolución de la leucemia linfoblástica aguda en la edad pediátrica en 29 años (1972-2000).
Vergara Domínguez, B; Cedré Hernández, T; Martínez Cárdenas, L; López García, C; González Seivane, F; Pichs León, V; Alegret Martínez, M; Pérez García, S; Courell Martin, G; Castro Martínez, M E.
Afiliação
  • Vergara Domínguez B; Hospital Pediátrico Universitario José Luis Miranda de Santa Clara, Villa Clara, Cuba. bvergara@capiro.vcl.sld.cu
An Pediatr (Barc) ; 64(1): 52-8, 2006 Jan.
Article em Es | MEDLINE | ID: mdl-16539917
OBJECTIVE: To evaluate the progress achieved in the treatment of acute lymphoblastic leukemia (ALL) in our hospital. MATERIAL AND METHODS: A total of 235 patients diagnosed with ALL in the central region of Cuba from 1972 to 2000 were included. Four groups were considered according to the diagnostic period and treatment protocol. Group 1 was composed of 20 patients who did not receive a uniform treatment regimen. The remaining groups were treated with different protocols of the Latin American Group for Malignant Hemopathy Therapy (Glathem). Group 2 was treated with less aggressive classical regimens from the 1970s, and groups 3 and 4 received more aggressive regimens, type Berlin-Frankfurt-Munster (BFM). Intravenous high-dose methotrexate was used in group 4 but not in group 3. Classification by prognostic groups was based on age and leukocyte count. RESULTS: Of 215 patients included in the Glathem protocols, remission occurred in 197 (91.6%). Overall survival in the distinct treatment groups progressively increased during the study period, from a 5-year survival of 15% in group 1 to 72% in group 4. Event-free survival in patients included in the Glathem protocols increased from 42% in group 2 (classical protocols) to 68.7% in the BFM protocols (groups 3 and 4). Significant differences were found among the different treatment and prognostic groups considered. CONCLUSIONS: During the period analyzed, survival in children with ALL progressively increased in parallel with improved treatment regimens. These results demonstrate the importance of well-programmed polychemotherapy to achieve prolonged survival and a high percentage of cure in this disease.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Guideline Limite: Child / Child, preschool / Humans / Infant Idioma: Es Revista: An Pediatr (Barc) Assunto da revista: PEDIATRIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Cuba País de publicação: Espanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Guideline Limite: Child / Child, preschool / Humans / Infant Idioma: Es Revista: An Pediatr (Barc) Assunto da revista: PEDIATRIA Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Cuba País de publicação: Espanha