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[Seropositivity for Chlamydia pneumoniae in patients with primary biliary cirrhosis]. / Seropositividad para Chlamydia pneumoniae en pacientes con cirrosis biliar primaria.
Montaño-Loza, A; Vázquez-Ballesteros, E; Meza-Junco, J; Villalobos-Zapata, I; Olivera-Martínez, M.
Afiliação
  • Montaño-Loza A; Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, Mexico. montanoa@quetzal.innsz.mx
Gastroenterol Hepatol ; 29(3): 113-7, 2006 Mar.
Article em Es | MEDLINE | ID: mdl-16507276
INTRODUCTION: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by inflammatory injury and bile duct destruction. Recent studies suggest that Chlamydia pneumoniae could be associated with the development of PBC. The aim of this study was to determine the seroprevalence of C. pneumoniae in a cohort of patients with PBC. PATIENTS AND METHODS: The presence of IgG antibodies against C. pneumoniae was investigated in 46 patients with PBC and in 105 subjects without cirrhosis. RESULTS: Twenty-one patients (46%) with PBC had antibodies against C. pneumoniae compared with 74 subjects (71%) in the control group (OR = 0.6; 95% CI, 0.3-1.2; p = NS). Subanalysis of the PBC group showed that patients with C. pneumoniae antibodies had a higher frequency of advanced Child-Pugh stages (24% A, 52% B and 24% C vs 64% A, 32% B and 4% C; p = 0.01), a higher score on the Mayo Clinic Prognostic Index (7.8 +/- 2.1 vs 5.6 +/- 1.2; p = 0.004), a higher frequency of ascites (29% vs 4%; OR = 9.6; 95% CI, 1-87; p = 0.02), higher total bilirubin levels (4.5 +/- 2.5 mg/dl vs 2.4 +/- 4.3 mg/dl, p = 0.001) and lower serum albumin levels (2.6 +/- 0.9 g/dl vs 3.3 +/- 0.6 g/dl, p = 0.02). CONCLUSION: No association was found between C. pneumoniae infection and PBC in this study. An association was found between the severity of PBC and C. pneumoniae, which may suggest a deleterious effect of C. pneumoniae infection or a predisposition in advanced stages of PBC to acquire infection with this microorganism.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chlamydophila pneumoniae / Cirrose Hepática Biliar / Anticorpos Antibacterianos Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: Es Revista: Gastroenterol Hepatol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: México País de publicação: Espanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chlamydophila pneumoniae / Cirrose Hepática Biliar / Anticorpos Antibacterianos Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: Es Revista: Gastroenterol Hepatol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: México País de publicação: Espanha