Comparison of the immune response elicited by infectious and inactivated foot-and-mouth disease virus in mice.
J Gen Virol
; 72 ( Pt 7): 1691-4, 1991 Jul.
Article
em En
| MEDLINE
| ID: mdl-1649903
The immune response to foot-and-mouth disease virus (FMDV) elicited by infection or immunization with inactivated virus in adult mice was examined. A model of adoptive transfer of immunocompetent cells was used for this purpose. The results presented here indicate that both short- and long-term secondary immune responses elicited by high doses of inactivated virus are indistinguishable, at the humoral or cellular level, from that observed after infection. The responses to inactivated or infectious virus were both efficiently mediated by B cells. However, immunization with low doses of inactivated virus induced a response which, although effective in aborting infection, was fully dependent on FMDV-specific T cell cooperation. These findings suggest that the different immune responses observed after infection and immunization are mainly the result of the different viral mass presented to the immune system in each case.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Aphthovirus
/
Anticorpos Antivirais
Tipo de estudo:
Prognostic_studies
Aspecto:
Patient_preference
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido