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Early and late effects of alcohol ingestion on blood pressure and endothelial function.
Bau, Paulo Fernando Dotto; Bau, Claiton H D; Naujorks, Alexandre A; Rosito, Guido A.
Afiliação
  • Bau PF; Department of Clinical Medicine, Health Sciences Centre, Federal University of Santa Maria, Rua Appel, 655/903, 97015-030 Santa Maria, RS, Brazil. paulobau@icardio.com.br
Alcohol ; 37(1): 53-8, 2005 Aug.
Article em En | MEDLINE | ID: mdl-16472719
Previous investigations have shown a biphasic effect of alcohol on blood pressure (BP). However, there are no studies on possible simultaneous influences in endothelial function. This study aims to evaluate the early and late effects of alcohol ingestion on vascular and endothelial function parameters in healthy young men. The diameter of brachial artery (DBA), endothelium-dependent flow-mediated dilatation, endothelium-independent nitroglycerin-mediated dilatation, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate were measured 30 min before intake, 4 h after intervention (when there is a reported hypotensive effect of alcohol), and after 13 h (subsequent increase in BP). The study group consisted of 100 males aged 18-25 years who were evaluated by brachial artery ultrasound. Subjects were randomized to drink either an alcoholic (60 g of ethanol) or a similar nonalcoholic beverage. Alcohol induced a biphasic effect on SBP and DBP, with a 4-h decrease followed by an increase after 13 h. After 4 h, the alcohol-drinking group presented a DBA increase that was significant at baseline and after hyperemia but not after nitroglycerin administration. There were no DBA differences between the intervention and control groups 13 h after drinking. This study replicates the initial reports of alcohol-induced biphasic alteration in BP. Our results showed that despite the late increase in BP, there were no accompanying changes in endothelial function.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Endotélio Vascular / Etanol Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Alcohol Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Endotélio Vascular / Etanol Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Alcohol Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos