Your browser doesn't support javascript.
loading
Formulation in tablets of a cholera whole cells inactivated vaccine candidate.
Talavera, A; Año, G; Pino, Y; Castaño, J; Uribarri, E; Riverón, L; Gil, S; Fernández, S; Cedré, B; Valmaseda, T; Pérez, J L; Infante, J F; García, L; Sierra, G.
Afiliação
  • Talavera A; Finlay Institut, 27 Ave. # 19805, La Lisa, Ciudad de la Habana, A.P. 16017, Cod. 11600, Cuba. atalavera@finlay.edu.cu
Vaccine ; 24(16): 3381-7, 2006 Apr 12.
Article em En | MEDLINE | ID: mdl-16460846
Licensed as well as candidate cholera vaccines available at the present requires the dose preparation (included buffer) at the moment of application. The aim of this work was to evaluate the presentation in oral tablets of an inactivated cholera vaccine to avoid that inconveniences during application. We have therefore compared inactivated cultures of Vibrio cholerae with tablets formulation vaccine. We obtained that antigenic activity (ELISA) and immunogenicity in animal model (ELISA and vibriocidal tests) of V. cholerae inactivated cell remained unaltered in the final tablet formulation. The results suggest that the oral tablet formulation could be a useful pharmaceutical form in order to produce a new and affordable cholera vaccine.
Assuntos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Cólera / Cólera Limite: Animals Idioma: En Revista: Vaccine Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Cuba País de publicação: Holanda
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas contra Cólera / Cólera Limite: Animals Idioma: En Revista: Vaccine Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Cuba País de publicação: Holanda