Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents.
Bioorg Med Chem Lett
; 16(5): 1312-5, 2006 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-16343898
The effect of several alkyl-linked bis tetrahydro-(2H)-1,3,5-thiadiazine-2-thione (bis-THTT) on Leishmania donovani, Trypanosoma brucei rhodesiense, and Plasmodium falciparum is reported. Most of the compounds exhibited a potent activity against the three parasitic strains but the best in vitro activity profiles were found against T. b. rhodesiense with IC(50) values ranging between 0.3 and 4 microM for the most active compounds.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiadiazinas
/
Tripanossomicidas
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Reino Unido