Hyperinsulinemic-euglycemic therapy for intoxication with calcium channel blockers.
Bol Asoc Med P R
; 97(3 Pt 2): 182-9, 2005.
Article
em En
| MEDLINE
| ID: mdl-16320908
Conventional therapy for intoxication with calcium channel blockers consists of crystalloid solutions, calcium gluconate, glucagon and vasopressor agents. These therapies often fail to improve hemodynamic function in intoxicated patients. The pathophysologic mechanism proposed for intoxication with these agents, suggest hypoinsulinemia as the determinant factor. We will describe the case of a 77 years old man treated for an overdose of nifedipine and atenolol who arrived at our institution with hypotension and bradycardia. After conventional therapy failed to improve the patient's hemodynamic status, hyperinsulinemia and euglycemia contributed to the improvement of the patient's neurologic and hemodynamic condition. Thus, hyperinsulinemic-euglycemic therapy was of benefit in this patient with hemodynamic compromise secondary to intoxication with calcium channel blocker not responding to conventional therapy. We will review the mechanism of action of calcium channel blocker drugs as well as the clinical presentation and treatment options for calcium channel blocker intoxication.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atenolol
/
Glucagon
/
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Glucose
/
Hiperinsulinismo
/
Hipoglicemiantes
/
Insulina
/
Antídotos
Tipo de estudo:
Prognostic_studies
Limite:
Aged
/
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Bol Asoc Med P R
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Porto Rico
País de publicação:
Porto Rico