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Glycosidation of cu,zn-superoxide dismutase with end-group aminated dextran: pharmacological and pharmacokinetics properties.
Perez, Yunel; Valdivia, Aimara; Gomez, Leissy; Simpson, Benjamin K; Villalonga, Reynaldo.
Afiliação
  • Perez Y; Enzyme Technology Group, University of Matanzas, Autopista a Varadero km 3 1/2, Matanzas, C.P. 44740, Cuba.
Macromol Biosci ; 5(12): 1220-5, 2005 Dec 15.
Article em En | MEDLINE | ID: mdl-16315187
Bovine Cu,Zn-SOD was chemically modified with an end-group aminated dextran derivative using a water-soluble carbodiimide as coupling agent. The enzyme retained 81% of the initial catalytic activity after the attachment of about 4.4 mol of polymer per protein subunit. The anti-inflammatory activity of the SOD was two times increased after conjugation with dextran. The modified enzyme was remarkably more resistant to inactivation by H(2)O(2) and its plasma half-life time was prolonged from 4 min to 3.2 h.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Dextranos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Macromol Biosci Assunto da revista: BIOQUIMICA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Dextranos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Macromol Biosci Assunto da revista: BIOQUIMICA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Cuba País de publicação: Alemanha