Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis.
Clin Exp Immunol
; 142(3): 411-8, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16297151
The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândulas Salivares
/
Sialadenite
/
Autoimunidade
/
Diabetes Mellitus Tipo 1
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido