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The Leogane, Haiti demonstration project: decreased microfilaremia and program costs after three years of mass drug administration.
de Rochars, Madsen Beau; Kanjilal, Sanjat; Direny, Abdel N; Radday, Jeanne; Lafontant, Jack G; Mathieu, Els; Rheingans, Richard D; Haddix, Anne C; Streit, Thomas G; Beach, Michael J; Addiss, David G; Lammie, Patrick J.
Afiliação
  • de Rochars MB; Hopital Ste. Croix, Leogane, Haiti.
Am J Trop Med Hyg ; 73(5): 888-94, 2005 Nov.
Article em En | MEDLINE | ID: mdl-16282299
To support the global program to eliminate lymphatic filariasis (LF), well-monitored demonstration projects are important for defining the relationship between coverage and reductions in microfilaremia. We are using mass treatment with diethylcarbamazine (DEC) and albendazole in an effort to eliminate LF from Leogane, Haiti. Wuchereria bancrofti microfilaremia prevalence at baseline ranged from 0.8% to 15.9% in four sentinel sites. After three rounds of DEC-albendazole mass drug administration (MDA), both microfilaremia prevalence and intensity decreased dramatically. Mild and moderate adverse reactions after treatment were common, especially after the first MDA, but decreased after subsequent MDAs. Drug coverage for the first year was estimated to be 72%, but concerns about adverse reactions appeared to decrease drug coverage in the second MDA. As a result of community education efforts that focused on providing a greater understanding of adverse reactions, coverage increased dramatically for the third round. Program efficiency increased substantially; the costs per person treated for three rounds of MDA were 2.23 US dollars, 1.96 US dollars, and 1.30 US dollars per person, respectively. The Leogane experience highlights the importance of adapting community education and mobilization campaigns to achieve and maintain good coverage.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Avaliação de Programas e Projetos de Saúde / Albendazol / Dietilcarbamazina / Filaricidas Tipo de estudo: Evaluation_studies / Health_economic_evaluation / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Caribe / Haiti Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Haiti País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Avaliação de Programas e Projetos de Saúde / Albendazol / Dietilcarbamazina / Filaricidas Tipo de estudo: Evaluation_studies / Health_economic_evaluation / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Caribe / Haiti Idioma: En Revista: Am J Trop Med Hyg Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Haiti País de publicação: Estados Unidos