Prevalence of Plasmodium falciparum mutations associated with antimalarial drug resistance during an epidemic in Kuna Yala, Panama, Central America.
Am J Trop Med Hyg
; 73(5): 839-41, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16282290
A molecular epidemiology study was conducted to determine the distribution of antimalarial drug resistance alleles among field isolates of Plasmodium falciparum. Samples were obtained during an epidemic affecting Kuna Amerindians in Panama. A high prevalence of mutations associated with chloroquine, pyrimethamine, and sulfadoxine was observed. Genotype analysis of msp2 revealed a low genetic diversity of P. falciparum parasites circulating in the studied area. The public health implications of these findings for the Central American region are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Resistência a Medicamentos
/
Surtos de Doenças
/
Malária Falciparum
/
Mutação
/
Antimaláricos
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
País/Região como assunto:
America central
/
Panama
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Panamá
País de publicação:
Estados Unidos