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The influence of newborn screening for cystic fibrosis on pulmonary outcomes in new South Wales.
McKay, Karen O; Waters, Donna L; Gaskin, Kevin J.
Afiliação
  • McKay KO; Department of Respiratory Medicine, The Children's Hospital at Westmead, The Children's Hospital at Westmead, Westmead, Australia. karenm8@chw.edu.au
J Pediatr ; 147(3 Suppl): S47-50, 2005 Sep.
Article em En | MEDLINE | ID: mdl-16202782
OBJECTIVES: To determine whether early treatment of cystic fibrosis made possible by diagnosis after newborn screening results in improved pulmonary outcomes in adolescence. STUDY DESIGN: Both screening (SG) and non-screening groups (NSG) comprised a cohort of children from Australia previously studied at 1, 5, and 10 years of age. The groups were compared on measures of clinical status obtained during their comprehensive annual review conducted at or near the 15th birthday of the subjects. RESULTS: Data were collected on 48 of 57 original subjects in the NSG (7 had died; 2 were lost to follow-up) and 52 of 60 original subjects in the SG (4 had died; 2 transferred out of the country; 2 were lost to follow-up). Those dying in the SG were significantly older (by 48 months, P < .05) than those in the NSG. No statistically significant differences were found between the groups in nutritional status. However, subjects in the SG displayed statistically better total Shwachman-Kulczycki scores (7.0, P
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triagem Neonatal / Fibrose Cística Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male / Newborn País/Região como assunto: Oceania Idioma: En Revista: J Pediatr Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triagem Neonatal / Fibrose Cística Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Male / Newborn País/Região como assunto: Oceania Idioma: En Revista: J Pediatr Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos