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Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe.
Sylvestre, Muriel; Pichette, André; Longtin, Angélique; Nagau, Francine; Legault, Jean.
Afiliação
  • Sylvestre M; Laboratoire d'analyse et de séparation des essences végétales, Département des Sciences fondamentales, Université du Québec à Chicoutimi, Qué., Canada.
J Ethnopharmacol ; 103(1): 99-102, 2006 Jan 03.
Article em En | MEDLINE | ID: mdl-16168586
The leaf essential oil of Croton flavens L., a native plant from the Caribbean area used in traditional medicine, was extracted by hydrodistillation. The composition of the volatile fraction of this essential oil was determined by GC and GC-MS analyses. We have identified 47 compounds, of which viridiflorene (12.22%), germacrone (5.27%), (E)-gamma-bisabolene (5.25%) and beta-caryophyllene (4.95%) are the main components. The anticancer activity of this extract was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line DLD-1. Croton flavens leaf essential oil was found to be very active against both tumor cell lines, with a GI(50) of 27 +/- 4 microg/ml for A-549 and 28 +/- 3 microg/ml for DLD-1. Three compounds identified in the leaf essential oil, alpha-cadinol (3.97%), beta-elemene (1.53%) and alpha-humulene (1.06%) are cytotoxic against tumor cell lines.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Folhas de Planta / Croton / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Guadalupe Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Canadá País de publicação: Irlanda
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Óleos Voláteis / Folhas de Planta / Croton / Antineoplásicos Fitogênicos Limite: Humans País/Região como assunto: Guadalupe Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Canadá País de publicação: Irlanda