Blockers of potassium current and resting membrane potential in rat muscle fibers.
Life Sci
; 51(3): 235-45, 1992.
Article
em En
| MEDLINE
| ID: mdl-1614288
Rat diaphragm fibers were equilibrated for several hours in 150 mM KCl; when they were returned to 5 mM KCl the resting potential went back to its original level with a half time of 17 min. This repolarization was blocked by 5 mM BaCl2, a blocker of the inward rectifier K channel. On the other hand, 0.1 mM apamin and 0.02 mM glibenclamide which block the Ca-dependent and ATP sensitive K channels, respectively, and 0.1 mM 9-AC a blocker of the Cl- channel did not affect the repolarization. 5 mM barium decreased the K conductance measured under current-clamp conditions in diaphragm muscle fibers. The possible role of the inward rectifier system in the repolarization following return to normal [K]o is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apamina
/
Canais de Potássio
/
Glibureto
/
Potenciais da Membrana
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Holanda