Changes in the gene expression profiling of the thymus in response to fibrosarcoma growth.
Mol Cell Biochem
; 276(1-2): 81-8, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16132688
The aim of this study was to determine whether subcutaneous injection of tumor cells into Balb-c mice, which induces a fibrosarcoma at the site of injection, produced a differential expression profile in the thymus that could be correlated with tumor growth. A dynamic transcriptional profile of the thymus in response to tumor development was observed using nylon cDNA microarrays. The Cluster-Tree View and the SAM programs were used to reveal induced and repressed genes during tumor growth. This experimental model-system showed that this approach is adequate to detect the presence of tumor cells in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Regulação Neoplásica da Expressão Gênica
/
Perfilação da Expressão Gênica
/
Fibrossarcoma
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda