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Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats.
Rossi, Andrea S; Lombardo, Yolanda B; Lacorte, Jean-Marc; Chicco, Adriana G; Rouault, Christine; Slama, Gérard; Rizkalla, Salwa W.
Afiliação
  • Rossi AS; Dept. of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, Paraje El Pozo C.C 242, 3000 Santa Fe, Argentina.
Am J Physiol Regul Integr Comp Physiol ; 289(2): R486-R494, 2005 Aug.
Article em En | MEDLINE | ID: mdl-16014450
Insulin resistance and adiposity induced by a long-term sucrose-rich diet (SRD) in rats could be reversed by fish oil (FO). Regulation of plasma leptin and adiponectin levels, as well as their gene expression, by FO might be implicated in these findings. This study was designed to evaluate the long-term regulation of leptin and adiponectin by dietary FO in a dietary model of insulin resistance induced by long-term SRD in rats and to determine their impact on adiposity and insulin sensitivity. Rats were randomized to consume a control diet (CD; n = 25) or an SRD (n = 50) for 7 mo. Subsequently, the SRD-fed rats were randomized to consume SRD+FO or to continue on SRD for an additional 2 mo. Long-term SRD induced overweight and decreased both plasma leptin and adiponectin levels without change in gene expression. Dyslipidemia, adiposity, and insulin resistance accompanied these modifications. Shifting the source of fat to FO for 2 mo increased plasma levels of both adipokines, reversed insulin resistance and dyslipidemia, and improved adiposity. These results were not associated with modifications in gene expression. These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gorduras Insaturadas na Dieta / Resistência à Insulina / Óleos de Peixe / Leptina / Peptídeos e Proteínas de Sinalização Intercelular / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Buscar no Google
Adicionar na Minha BVS
Imprimir
XML
PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gorduras Insaturadas na Dieta / Resistência à Insulina / Óleos de Peixe / Leptina / Peptídeos e Proteínas de Sinalização Intercelular / Obesidade Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Am J Physiol Regul Integr Comp Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos