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[Population pharmacokinetics of carbamazepine in adults with epilepsy]. / Farmacocinética poblacional de carbamacepina en pacientes epilépticos adultos.
Rev Invest Clin ; 57(1): 38-48, 2005.
Article em Es | MEDLINE | ID: mdl-15981957
The aim of the present study was to determinate the factors affecting carbamazepine (CBZ) clearance (CL) in adults with epilepsy using a mixed-effect model and sparse data collected during routine clinical care. The patient population comprised 104 adults receiving CBZ. A total of 161 CBZ steady state serum concentration samples were analyzed. Population CL was calculated by using NONMEM with a one compartment model with first-order absorption and elimination. The following covariates were tested for their influence on clearance (CL): total body weight, age, dose/day, sex, surface area (SA) and comedication with primidone (PRIM), ualproic acid or phenytoin (DFH). The final regression model for carbamazepine clearance found best to describe the data was: CL = (0.614 SA + 0.0016 dose/day)(1 + 0.278 DFH)(1 + 0.326 PRIM).
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamazepina / Epilepsia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Rev Invest Clin Assunto da revista: MEDICINA Ano de publicação: 2005 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbamazepina / Epilepsia Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: Es Revista: Rev Invest Clin Assunto da revista: MEDICINA Ano de publicação: 2005 Tipo de documento: Article País de publicação: México