Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis.

Henao, Marcela I; Montes, Carlos; París, Sara C; García, Luis F

Henao, Marcela I; Montes, Carlos; París, Sara C; García, Luis F.

Afiliação

Henao MI; Grupo de Inmunología Celular e Inmunogenética, Sede de Investigación Universitaria, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.

Tuberculosis (Edinb) ; 86(1): 11-9, 2006 Jan.

Article em En | MEDLINE | ID: mdl-15925543

RESUMO

Tuberculosis (TB) has different clinical presentations. Pulmonary TB affects only the lungs and exhibits variable anti-mycobacterial immune responses. Pleural TB is a localized disease with a strong immune response. Miliary TB is a disseminated form with poor immune response. Cytokines play a pivotal role in anti-mycobacterial response and may determine the type of TB. Thus, gene polymorphisms associated with cytokine production may be associated with clinical presentations of TB. In this study, 54 tuberculin-negative healthy controls, 81 tuberculin-positive healthy controls, 140 patients with pulmonary TB, 30 with pleural TB and 20 with miliary TB were studied. Single nucleotide polymorphisms were typed for tumour necrosis factor-alpha, interferon-gamma (IFN-gamma), transforming growth factor-beta1, interleukin-10 (IL-10) and interleukin-6 by sequence-specific primer polymerase chain reaction (SSP-PCR). Allelic, genotypic and haplotypic associations with clinical forms of TB were evaluated. IL-10 -1082 A/A genotype and IFNgamma+874 T allele were associated with pleural TB. Seventy-five extended genotypes were found; two differed between patients and controls, and two between groups of patients. Results suggest that IL-10 low-producer polymorphism and IFN-gamma high-producer polymorphism are associated with pleural TB.

Assuntos

Citocinas/genética; Polimorfismo Genético/genética; Tuberculose Miliar/genética; Tuberculose Pleural/genética; Tuberculose Pulmonar/genética; Adolescente; Adulto; Idoso; Estudos de Casos e Controles; Colômbia; Feminino; Humanos; Interferon gama/genética; Interleucina-10/genética; Interleucina-6/genética; Masculino; Pessoa de Meia-Idade; Fator de Crescimento Transformador beta/genética; Fator de Necrose Tumoral alfa/genética

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Tuberculose Miliar / Tuberculose Pleural / Tuberculose Pulmonar / Citocinas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Colombia Idioma: En Revista: Tuberculosis (Edinb) Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Reino Unido

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