In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.
Brain Res
; 1043(1-2): 186-94, 2005 May 10.
Article
em En
| MEDLINE
| ID: mdl-15862532
Several morphological works have shown that the globus pallidus (GP) contains the highest density of 5-HT1B receptors within the telencephalon. However, the role of these receptors in the spiking of GP neurons in vivo is unknown. In the present work, we use single-unit extracellular recordings in the anesthetized rat to analyze changes in the firing rate of GP neurons evoked by local activation and blockade of 5-HT1B receptors. Intrapallidal administration of serotonin, or the serotonin uptake inhibitor fluoxetine, predominantly produced an excitatory effect in the basal firing rate of GP neurons. The 5-HT1B receptor agonist, L-694,247, caused a dose-dependent excitatory effect on most pallidal neurons tested. Blockade of 5-HT1B receptors by intrapallidal application of methiothepin predominantly caused inhibition in GP neurons firing rate. Moreover, methiothepin diminished the excitatory effect evoked by L-694,247. Furthermore, local serotonin did not evoke significant changes in the basal firing rate of GP neurons in unilateral striatal lesioned rats. Taken all together, these results suggest that serotonin 5-HT1B receptors significantly contribute to the control of spiking of the rat GP neurons, and that the 5-HT1B receptors exerting this control are most likely localized in the striato-pallidal pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Potenciais de Ação
/
Triptaminas
/
Receptor 5-HT1B de Serotonina
/
Antagonistas do Receptor 5-HT1 de Serotonina
/
Globo Pálido
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Holanda