Ontogenetic changes in serum S100B in Down syndrome patients.
Clin Biochem
; 38(5): 433-5, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-15820773
BACKGROUND: It has been shown that Down syndrome (DS) patients have elevated S100B levels in brain tissue. DESIGN: Measurements of S100B were performed in serum samples from 48 DS patients and 42 ostensibly healthy age-matched controls. RESULTS: We observed higher levels of S100B in the DS group than in the control group. Moreover, serum S100B in DS patients was not age-dependent as it is in normal individuals. CONCLUSION: The higher levels of S100B in DS patients may reflect a general and persistent increase in the extracellular space and may be associated with neurodegenerative lesions observed in DS patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
/
Síndrome de Down
/
Fatores de Crescimento Neural
Limite:
Child
/
Child, preschool
/
Humans
/
Infant
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos