Ontogenetic changes in serum S100B in Down syndrome patients.

Netto, Cristina B O; Portela, Luis V; Ferreira, Cristina T; Kieling, Carlos; Matte, Ursula; Felix, Têmis; da Silveira, Themis Reverbel; Souza, Diogo O; Gonçalves, Carlos-Alberto; Giugliani, Roberto

Netto, Cristina B O; Portela, Luis V; Ferreira, Cristina T; Kieling, Carlos; Matte, Ursula; Felix, Têmis; da Silveira, Themis Reverbel; Souza, Diogo O; Gonçalves, Carlos-Alberto; Giugliani, Roberto.

Afiliação

Netto CB; Dept. Bioquimica, ICBS, UFRGS, Rua Euripedes Monteiro Duarte 10/305, Porto Alegre, RS, 90830-250, Brazil. cristina.netto@ufrgs.br

Clin Biochem ; 38(5): 433-5, 2005 May.

Article em En | MEDLINE | ID: mdl-15820773

RESUMO

BACKGROUND: It has been shown that Down syndrome (DS) patients have elevated S100B levels in brain tissue. DESIGN: Measurements of S100B were performed in serum samples from 48 DS patients and 42 ostensibly healthy age-matched controls. RESULTS: We observed higher levels of S100B in the DS group than in the control group. Moreover, serum S100B in DS patients was not age-dependent as it is in normal individuals. CONCLUSION: The higher levels of S100B in DS patients may reflect a general and persistent increase in the extracellular space and may be associated with neurodegenerative lesions observed in DS patients.

Assuntos

Síndrome de Down/sangue; Fatores de Crescimento Neural/sangue; Proteínas S100/sangue; Envelhecimento; Criança; Pré-Escolar; Humanos; Lactente; Subunidade beta da Proteína Ligante de Cálcio S100

Buscar no Google

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas S100 / Síndrome de Down / Fatores de Crescimento Neural Limite: Child / Child, preschool / Humans / Infant Idioma: En Revista: Clin Biochem Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Buscar no Google

Adicionar na Minha BVS

Imprimir

XML

PubMed Links