Anti-Trypanosoma-cruzi-proteinase antibodies and immunoprotection in experimental Chagas' disease.

Sakurada, J K; Maury, A; Tamashiro, W M; Araújo, P M; Camargo, I J; Rangel, H A

Sakurada, J K; Maury, A; Tamashiro, W M; Araújo, P M; Camargo, I J; Rangel, H A.

Afiliação

Sakurada JK; Depto. Microbiologia e Imunologia, Instituto de Biologia, UNICAMP, São Paulo, Brazil.

Res Immunol ; 143(2): 157-64, 1992 Feb.

Article em En | MEDLINE | ID: mdl-1574641

RESUMO

To verify whether anti-Trypanosoma-cruzi-proteinase antibodies are able to play a role in the development of Chagas' disease, CBA/J and C57BL/6 mice were immunized with purified proteinase fractions: antibody production was studied and passive immunization experiments were carried out. No significant differences were observed in the titre, isotype composition and specificity of the antibodies produced by the mouse strains. Immune sera produced in one strain was able to protect mice of both strains, provided that the challenge did not exceed the number of parasites corresponding to 30-fold the LD50. The data presented suggest that anti-proteinase antibodies may play a role in immunoprotection.

Assuntos

Anticorpos Antiprotozoários/biossíntese; Doença de Chagas/imunologia; Endopeptidases/imunologia; Trypanosoma cruzi/imunologia; Animais; Doença de Chagas/prevenção & controle; Modelos Animais de Doenças; Feminino; Imunização Passiva; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos CBA; Trypanosoma cruzi/enzimologia

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endopeptidases / Trypanosoma cruzi / Anticorpos Antiprotozoários / Doença de Chagas Limite: Animals Idioma: En Revista: Res Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 1992 Tipo de documento: Article País de afiliação: Brasil País de publicação: França

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