[Neuropharmacological aspects of chronic alcohol use and withdrawal syndrome]. / Aspectos neurofarmacológicos do uso crônico e da síndrome de abstinência do alcool.
Braz J Psychiatry
; 26 Suppl 1: S40-2, 2004 May.
Article
em Pt
| MEDLINE
| ID: mdl-15729443
The objective of this paper is to review and describe the main neuropharmacological changes caused by the chronic use of alcohol and those observed during its withdrawal period. The results show international data referring to the involvement of monoamine systems, neurotransmitters and calcium channels in both neuroadaptation and tolerance to alcohol effects and withdrawal. Relevant studies showing the participation of other systems in those mechanisms, as opioids and other substances, are also shown. The article reinforces the importance, for both physicians and researchers, of an always growing understanding of alcohol central mechanisms of action. This understanding is necessary to new pharmacological options to alcohol harm reduction as well as to alcohol withdrawal treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurotransmissores
/
Delirium por Abstinência Alcoólica
/
Alcoolismo
Limite:
Humans
Idioma:
Pt
Revista:
Braz J Psychiatry
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil