DNA-binding properties of cosmomycin D, an anthracycline with two trisaccharide chains.
J Antibiot (Tokyo)
; 57(10): 647-54, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15638325
Cosmomycin D (CosD) is the major constituent fraction isolated from a culture of Streptomyces olindensis ICB20. The ability of this compound to intercalate with double-stranded DNA was studied by gel mobility shift assays and electrospray ionization mass spectrometry (ESI-MS). ESI-MS experiments showed that the complex of CosD with 16-mer double-stranded DNA was at least as stable as a complex of daunorubicin with the same DNA sequence. This is the first study showing DNA binding properties of an anthracycline containing a beta-rhodomycinone aglycone chromophore O-linked to two trisaccharide chains.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Antraciclinas
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido