Relationship between gene polymorphisms and prevalence of myocardial infarction among diabetic and non-diabetic subjects.

Relvas, W G M; Izar, M C O; Helfenstein, T; Fonseca, M I H; Colovati, M; Oliveira, A; Ihara, S S M; Han, S W; Las Casas, A A; Fonseca, F A H

Relvas, W G M; Izar, M C O; Helfenstein, T; Fonseca, M I H; Colovati, M; Oliveira, A; Ihara, S S M; Han, S W; Las Casas, A A; Fonseca, F A H.

Afiliação

Relvas WG; Lipides, Aterosclerose e Biologia Vascular, Disciplina de Cardiologia-Universidade Federal de São Paulo, UNIFESP, Rua Pedro de Toledo 458, São Paulo 04039-001, Brazil.

Atherosclerosis ; 178(1): 101-5, 2005 Jan.

Article em En | MEDLINE | ID: mdl-15585206

RESUMO

This study was aimed to examine cholesteryl ester transfer protein (CETP), apolipoprotein AI and CIII gene polymorphisms, and to verify whether these genetic determinants are associated with the prevalence of myocardial infarction (MI) or type 2 diabetes. The TaqIB restriction fragment length polymorphism (RFLP) in intron I of the CETP gene, the MspI in the third intron of the APOAI gene, and also SstI in the 3' untranslated region of the APOCIII gene were determined using standard methods. The prevalence of these polymorphisms was compared between diabetic (n = 119), and non-diabetic (n = 100) middle-aged individuals of both sexes. We found a higher prevalence of the B2B2 genotype of the CETP gene among diabetics than that observed in non-diabetics (P < 0.05), and a lower prevalence of this genotype among patients with previous MI (P < 0.02). The MspI polymorphisms of the APOAI gene showed that M1++ genotype was found mainly in diabetic patients (P < 0.04). Conversely, the SstI polymorphism of APOCIII gene was not significantly associated with either MI or diabetes. Therefore, among these genetic polymorphisms, TaqIB of CETP and MspI of apolipoprotein AI appeared to help significantly to identify diabetic individuals. In particular, the former may have an additional role in the primary prevention of coronary disease.

Assuntos

Apolipoproteína A-I/genética; Apolipoproteínas C/genética; Proteínas de Transporte/genética; Diabetes Mellitus Tipo 2/genética; Predisposição Genética para Doença; Glicoproteínas/genética; Infarto do Miocárdio/genética; Polimorfismo Genético; Apolipoproteína C-III; Estudos de Casos e Controles; Proteínas de Transferência de Ésteres de Colesterol; Diabetes Mellitus Tipo 2/sangue; Feminino; Humanos; Lipídeos/sangue; Lipoproteínas/sangue; Masculino; Pessoa de Meia-Idade

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas C / Polimorfismo Genético / Glicoproteínas / Proteínas de Transporte / Apolipoproteína A-I / Predisposição Genética para Doença / Diabetes Mellitus Tipo 2 / Infarto do Miocárdio Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Atherosclerosis Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda

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