Induction of experimental mammary carcinogenesis in rats with 7,12-dimethylbenz(a)anthracene.
Rev Hosp Clin Fac Med Sao Paulo
; 59(5): 257-61, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15543396
PURPOSE: To test an experimental model of chemical mammary carcinogenesis induction in rats. METHODS: Twenty young virgin Sprague-Dawley female rats, aged 47 days, received 20 mg of 7,12-dimethylbenz(a)anthracene (DMBA) intragastrically by gavage. Afterwards, at 8 and 13 weeks, their mammary glands were examined. At the end of the experiment, the animals were sacrificed, and the mammary tumors were measured and weighed. Tumor fragments were analyzed using light microscopy. RESULTS: Eight weeks after DMBA injection, 16 rats presented at least 1 breast tumor (80%). After 13 weeks, all of them (100%) developed breast carcinomas that were confirmed by histopathological analysis. CONCLUSION: This experimental animal model of chemical mammary induced carcinogenesis is feasible and can be used in further experiments on the role of tumorigenic biomodulator substances.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinógenos
/
Carcinoma
/
9,10-Dimetil-1,2-benzantraceno
/
Neoplasias Mamárias Experimentais
Limite:
Animals
Idioma:
En
Revista:
Rev Hosp Clin Fac Med Sao Paulo
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil