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Effectiveness and acceptability of vitamin E and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding.
d'Arcangues, Catherine; Piaggio, Gilda; Brache, Vivian; Aissa, Rim Ben; Hazelden, Catherine; Massai, Rebeca; Pinol, Alain; Subakir, Sri Bekti; Su-juan, Gu.
Afiliação
  • d'Arcangues C; Special Programme of Research, World Health Organization, Development and Research Training in Human Reproduction (HRP), CH-1211-Geneva-27, Switzerland. darcanguesc@who.int
Contraception ; 70(6): 451-62, 2004 Dec.
Article em En | MEDLINE | ID: mdl-15541406
A study (ISRCTN 77665712) was undertaken to test the effectiveness and the acceptability of vitamin E and low-dose aspirin, alone or in combination, as treatment for prolonged vaginal bleeding induced by Norplant. A total of 486 Norplant users who were requesting treatment for bleeding lasting longer than 7 days were enrolled in five centers: Beijing, China; Jakarta, Indonesia; Santiago, Chile; Santo Domingo, Dominican Republic; and Tunis, Tunisia. They were randomized to one of four different 10-day oral treatments: 200 mg vitamin E daily, 80 mg aspirin daily, both or a placebo. Treatment packs were designed to ensure blinding of both the subjects and the clinical staff. Neither vitamin E nor low-dose aspirin nor their combination was found to have any effect on reducing the length of the bleeding episode for which treatment was taken or on the vaginal bleeding patterns these women experienced during the year of follow-up.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Uterina / Vitamina E / Anti-Inflamatórios não Esteroides / Aspirina / Levanogestrel Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans País/Região como assunto: Africa / America do sul / Asia / Chile / Republica dominicana Idioma: En Revista: Contraception Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemorragia Uterina / Vitamina E / Anti-Inflamatórios não Esteroides / Aspirina / Levanogestrel Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans País/Região como assunto: Africa / America do sul / Asia / Chile / Republica dominicana Idioma: En Revista: Contraception Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos