Effectiveness and acceptability of vitamin E and low-dose aspirin, alone or in combination, on Norplant-induced prolonged bleeding.
Contraception
; 70(6): 451-62, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15541406
A study (ISRCTN 77665712) was undertaken to test the effectiveness and the acceptability of vitamin E and low-dose aspirin, alone or in combination, as treatment for prolonged vaginal bleeding induced by Norplant. A total of 486 Norplant users who were requesting treatment for bleeding lasting longer than 7 days were enrolled in five centers: Beijing, China; Jakarta, Indonesia; Santiago, Chile; Santo Domingo, Dominican Republic; and Tunis, Tunisia. They were randomized to one of four different 10-day oral treatments: 200 mg vitamin E daily, 80 mg aspirin daily, both or a placebo. Treatment packs were designed to ensure blinding of both the subjects and the clinical staff. Neither vitamin E nor low-dose aspirin nor their combination was found to have any effect on reducing the length of the bleeding episode for which treatment was taken or on the vaginal bleeding patterns these women experienced during the year of follow-up.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Uterina
/
Vitamina E
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Anti-Inflamatórios não Esteroides
/
Aspirina
/
Levanogestrel
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
País/Região como assunto:
Africa
/
America do sul
/
Asia
/
Chile
/
Republica dominicana
Idioma:
En
Revista:
Contraception
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Suíça
País de publicação:
Estados Unidos