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Primary meningeal Epstein-Barr virus-related leiomyosarcoma in a man infected with human immunodeficiency virus: review of literature, emphasizing the differential diagnosis and pathogenesis.
Zevallos-Giampietri, Eduardo-Alfredo; Yañes, Hugo Heinicke; Orrego Puelles, José; Barrionuevo, Carlos.
Afiliação
  • Zevallos-Giampietri EA; Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Appl Immunohistochem Mol Morphol ; 12(4): 387-91, 2004 Dec.
Article em En | MEDLINE | ID: mdl-15536343
We describe the clinical, radiologic, surgical, and pathologic findings of a 29-year-old Peruvian human immunodeficiency virus-infected man with a primary parasellar meningeal leiomyosarcoma involving the left lesser esphenoidal wing and the cavernous sinus. Over a period of 13 months, he developed headache, vomiting, insomnia, and diplopia. Magnetic resonance imaging revealed a left parasellar extra-axial mass that was isointense in T1, hypointense in T2, and gadolinium-enhanced. The patient underwent subtotal resection of the tumor. The neoplasm was composed of spindle cells with smooth-muscle features. It showed moderate atypia, inconspicuous nucleoli, and scanty mitosis. No tumor necrosis was detected. The immunohistochemistry revealed strong positivity for vimentin, desmin, and smooth-muscle alpha-actin. A low-grade leiomyosarcoma was diagnosed. The in situ hybridization showed positive nuclear reactivity for Epstein-Barr virus-encoded RNA. The immunohistochemistry was negative for Epstein-Barr virus latent membrane protein 1. The main differential diagnosis of primary meningeal smooth-muscle tumors includes meningioma and peripheral nerve sheath tumors. Epstein-Barr virus has been demonstrated in most smooth-muscle tumors associated with acquired immune deficiency syndrome (AIDS). Primary meningeal smooth-muscle tumors, exceedingly rare neoplasms, remarkably affect young adults with AIDS. Comparatively, most AIDS-related visceral (nonmeningeal) smooth-muscle tumors have been reported in children. The permissiveness and tumorigenesis associated with Epstein-Barr virus may depend on the age of human immunodeficiency virus infection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Herpesvirus Humano 4 / Leiomiossarcoma / Neoplasias Meníngeas Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Adult / Humans / Male Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Herpesvirus Humano 4 / Leiomiossarcoma / Neoplasias Meníngeas Tipo de estudo: Diagnostic_studies / Etiology_studies Limite: Adult / Humans / Male Idioma: En Revista: Appl Immunohistochem Mol Morphol Assunto da revista: BIOLOGIA MOLECULAR / HISTOCITOQUIMICA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Peru País de publicação: Estados Unidos