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Angiotensin-converting enzyme gene polymorphism in preeclampsia and normal pregnancy.
Galão, Adriani O; de Souza, Lívia H; da Costa, Bartira E Pinheiro; Scheibe, Rosane M; Poli de Figueiredo, Carlos E.
Afiliação
  • Galão AO; Programa de Pós-graduação em Clnica Médica e Ciências da Saúde (Nefrologia), Instituto de Pesquisas Biomédicas/Faculdade de Medicina/Hospital São Lucas, Pontifcia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Am J Obstet Gynecol ; 191(3): 821-4, 2004 Sep.
Article em En | MEDLINE | ID: mdl-15467548
OBJECTIVE: The purpose of this study was to evaluate the angiotensin-converting enzyme gene polymorphism in pregnant women with and without preeclampsia. STUDY DESIGN: Preeclampsia was defined as hypertension and pathologic proteinuria in pregnant women after gestational week 20. Genomic DNA was isolated from leukocytes. The insertion-deletion polymorphism in intron 16 of the angiotensin-converting enzyme gene was detected in DNA samples with the use of the polymerase chain reaction. Chi-squared and Student t tests were used for statistical analysis. RESULTS: In preeclampsia (n=51 women) angiotensin-converting enzyme genotypes were deletion-D (DD) in 16 women (31%), insertion-I (II) in 12 women (24%), and insertion-deletion in 23 women (45%); in the control group (n=71), the angiotensin-converting enzyme genotypes were DD in 21 women (30%), II in 17 women (24%), and insertion-deletion in 33 women (46%). Angiotensin-converting enzyme genotype distribution and allelic frequencies were not different between groups. CONCLUSION: No difference in the angiotensin-converting enzyme genotype distribution was found between preeclampsia and normal pregnancy. The results showed no association between angiotensin-converting enzyme polymorphism and the development of preeclampsia.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Pré-Eclâmpsia / Peptidil Dipeptidase A Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Pré-Eclâmpsia / Peptidil Dipeptidase A Limite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos