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Neutrophils as a specific target for melatonin and kynuramines: effects on cytokine release.
Silva, S O; Rodrigues, M R; Ximenes, V F; Bueno-da-Silva, A E B; Amarante-Mendes, G P; Campa, A.
Afiliação
  • Silva SO; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo CEP 05508-900, SP, Brazil.
J Neuroimmunol ; 156(1-2): 146-52, 2004 Nov.
Article em En | MEDLINE | ID: mdl-15465605
A growing body of evidence suggests that the pineal hormone, melatonin, has immunomodulatory properties, although very little is known about its effect on leukocytes. Therefore, we aimed to investigate the effect of melatonin and its oxidation product N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) on cytokine production by neutrophils and peripheral blood mononuclear cells (PBMCs). AFMK (0.001-1 mM) inhibits the lipopolysaccharide (LPS)-mediated production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) more efficiently in neutrophils than PBMCs. Moreover, the inhibitory activity of AFMK is stronger than that of melatonin. Interestingly, monocytes efficiently oxidize melatonin to AFMK. We conclude that neutrophils are one of the main targets for melatonin and that at least part of the effects described for melatonin on immune cells may be due to its oxidation product, AFMK. We also consider that the oxidation of melatonin may be an important event in the cross-talking between neutrophils and monocytes.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Cinuramina / Melatonina / Neutrófilos Limite: Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citocinas / Cinuramina / Melatonina / Neutrófilos Limite: Humans Idioma: En Revista: J Neuroimmunol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda