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Immunogenicity of Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine in children with sickle hemoglobinopathy or malignancies, and after systemic Haemophilus influenzae type b infection.
Kaplan, S L; Duckett, T; Mahoney, D H; Kennedy, L L; Dukes, C M; Schaffer, D M; Mason, E O.
Afiliação
  • Kaplan SL; Department of Pediatrics, Baylor College of Medicine, Houston, TX.
J Pediatr ; 120(3): 367-70, 1992 Mar.
Article em En | MEDLINE | ID: mdl-1538281
To determine the immunogenicity of Haemophilus influenzae type b polysaccharide-tetanus protein conjugate vaccine in specific populations at risk, we administered vaccine to children with sickle cell anemia (n = 19; mean age, 18.3 months, malignancies (n = 18; mean age, 43.1 months), or a recent history of systemic H. influenzae type b infection (n = 17; mean age, 11.9 months). After one dose of polyribosylribitol phosphate-tetanus toxoid conjugate vaccine the geometric mean titers for polyribosylribitol phosphate antibody were 4.8 micrograms/ml (14/19 greater than 1 microgram/ml), 1.4 micrograms/ml (9/18 greater than 1 microgram/ml), and 5.6 micrograms/ml (15/17 greater than 1 microgram/ml) in these three groups, respectively. Children with sickle cell anemia or a recent history of systemic H. influenzae type b infection had polyribosylribitol phosphate antibody levels comparable to those of normal children of similar age after one or two doses of polyribosylribitol phosphate-tetanus toxoid conjugate vaccine. We conclude that this vaccine is immunogenic in children with underlying conditions associated with an increased risk of H. influenzae type b infection.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Bacterianas / Toxoide Tetânico / Haemophilus influenzae / Vacinas Anti-Haemophilus / Infecções por Haemophilus / Anemia Falciforme / Anticorpos Antibacterianos / Neoplasias Limite: Child, preschool / Humans / Infant Idioma: En Revista: J Pediatr Ano de publicação: 1992 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas Bacterianas / Toxoide Tetânico / Haemophilus influenzae / Vacinas Anti-Haemophilus / Infecções por Haemophilus / Anemia Falciforme / Anticorpos Antibacterianos / Neoplasias Limite: Child, preschool / Humans / Infant Idioma: En Revista: J Pediatr Ano de publicação: 1992 Tipo de documento: Article País de publicação: Estados Unidos