[Cytochrome P450 activity and its alteration in different diseases]. / Actividad del citocromo P450 y su alteración en diversas patologías.
Rev Med Chil
; 132(1): 85-94, 2004 Jan.
Article
em Es
| MEDLINE
| ID: mdl-15379059
Cytochrome P450 (CYP) enzymes participate in the metabolism of a variety of naturally occurring and foreign compounds by reactions requiring NADPH and O2. The diversity of reactions catalyzed and its extensive substrate specificity render CYP enzymes as one of the most versatile known catalysts. Individual members of the CYP superfamily are expressed in almost every cell type in the body. As compared to hepatic enzymes, the regulation of human extrahepatic CYPs has not been so well studied. In general, the levels of some hepatic CYP enzymes are depressed by diseases, causing potential and documented impairment of drug clearence and clinical drug toxicity. However, modulation of CYPs is enzyme selective and this selectivity differs in different diseases. This article reviews some basic concepts about CYP and its regulation in some disease states such as hypertension, diabetes, obesity and hepatic, infectious and inflammatory diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença
/
Sistema Enzimático do Citocromo P-450
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Rev Med Chil
Ano de publicação:
2004
Tipo de documento:
Article
País de publicação:
Chile