Kinetics of phosphofructokinase from granulocytes isolated from patients with insulin resistance.
Biochem Biophys Res Commun
; 185(2): 559-66, 1992 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-1535194
Phosphofructokinases from granulocytes isolated from insulin-resistant patients, mainly those from type II diabetics where the degree of insulin resistance was more pronounced, exhibit some changes in their kinetic behavior when assayed under allosteric conditions, characterized by an increased affinity for fructose-6-phosphate, being more resistant to ATP inhibition while it became more sensitive to citrate inhibitory effect. Those changes are suggestive of a isozymic modification to a more L-type enriched enzyme with a loss of the F-type component, probably present in the normal granulocyte.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Fosfofrutoquinase-1
/
Granulócitos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Venezuela
País de publicação:
Estados Unidos