Genetic studies suggest a novel Portuguese origin for hemoglobin Porto Alegre.
Haematologica
; 89(8): 1009-10, 2004 Aug.
Article
em En
| MEDLINE
| ID: mdl-15339686
Molecular studies performed in Portuguese and Brazilian cases of hemoglobin Porto Alegre [beta9 Ser->Cys] revealed that the mutation is in association with the Mediterranean haplotype I and framework 1 and that it is also in cis with an undescribed intragenic polymorphism (codon 27, GCC->GCT). Based upon these findings, and reinforced by historical data, we suggest that hemoglobin Porto Alegre originated from a single mutational event in the Portuguese population and was then spread to South America, namely to Brazil.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas Anormais
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
/
Europa
Idioma:
En
Revista:
Haematologica
Ano de publicação:
2004
Tipo de documento:
Article
País de publicação:
Itália