Temperature effects on a whole metabolic reaction cannot be inferred from its components.
Proc Biol Sci
; 271(1546): 1415-9, 2004 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-15306341
Changes in temperature affect the kinetic energy of the constituents of a system at the molecular level and have pervasive effects on the physiology of the whole organism. A mechanistic link between these levels of organization has been assumed and made explicit through the use of values of organismal Q10 to infer control of metabolic rate. To be valid this postulate requires linearity and independence of the isolated reaction steps, assumptions not accepted by all. We address this controversy by applying dynamic systems theory and metabolic control analysis to a metabolic pathway model. It is shown that temperature effects on isolated steps cannot rigorously be extrapolated to higher levels of organization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Temperatura
/
Metabolismo Energético
/
Modelos Biológicos
Idioma:
En
Revista:
Proc Biol Sci
Assunto da revista:
BIOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Reino Unido