Lithium effects on estrogen-induced dopaminergic supersensitivity in rats.
Brain Res Bull
; 29(2): 239-41, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1525677
The effect of lithium (2.0 mEq/kg, IP) on dopaminergic supersensitivity induced by long-term estrogen treatment (0.25 mg/day, SC) was investigated. Ovariectomized rats were treated for 28 days with estrogen and/or lithium and 6 days after the last administration all animals were observed for apomorphine-induced stereotyped behavior (1.0 mg/kg, SC). The abrupt withdrawal from long-term estrogen treatment increased rats' sensitivity to apomorphine but lithium administration was able to prevent this increase. Lithium alone produced no effect on stereotyped behavior. It was suggested that lithium may antagonize the estrogen effect on the nigrostriatal dopamine system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Dopaminérgicos
/
Estrogênios
/
Lítio
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Estados Unidos