Stability of liposomal formulations in physiological conditions for oral drug delivery.

Taira, M C; Chiaramoni, N S; Pecuch, K M; Alonso-Romanowski, S

Taira, M C; Chiaramoni, N S; Pecuch, K M; Alonso-Romanowski, S.

Afiliação

Taira MC; Laboratory of Biomembranes, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina.

Drug Deliv ; 11(2): 123-8, 2004.

Article em En | MEDLINE | ID: mdl-15200011

RESUMO

The stability of liposomal formulations is a key issue in drug delivery. Liposomes made of egg phosphatidylcholine (EPC), cholesterol (Chol), sphingomyelin (SM), and gangliosides (GM1 and GM type III) were incubated in different media to determine their stability. Mixtures containing GM1 or GM type III were found to be the most stable, and both showed similar stability trends in plasma at 37 degrees C. EPC/Chol was the most susceptible to lysis in plasma. In acid media (pH 2), the highest stability corresponded to EPC/Chol, whereas in bile and pancreatin, liposomes with GM1 and GM type III were more stable than those containing SM. This study suggests that among the formulations used as oral drug carriers, those containing GM1 and GM type III have higher possibilities of surviving through the gastrointestinal tract.

Assuntos

Sistemas de Liberação de Medicamentos/métodos; Lipossomos/administração & dosagem; Lipossomos/metabolismo; Administração Oral; Animais; Bovinos; Química Farmacêutica; Estabilidade de Medicamentos; Humanos; Suínos

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Lipossomos Limite: Animals / Humans Idioma: En Revista: Drug Deliv Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido

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