Your browser doesn't support javascript.
loading
Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats.
Pepato, Maria Teresa; Baviera, Amanda Martins; Vendramini, Regina Célia; Brunetti, Iguatemy Lourenço.
Afiliação
  • Pepato MT; Department of Clinical Analyses, Araraquara School of Pharmacy, São Paulo State University (UNESP), Araraquara, SP, Brazil. pepatomt@fcfar.unesp.br
BMC Complement Altern Med ; 4: 7, 2004 Jun 08.
Article em En | MEDLINE | ID: mdl-15186500
BACKGROUND: Previous experiments have shown that a decoction of Bauhinia forficata leaves reduces the changes in carbohydrate and protein metabolism that occur in rats with streptozotocin-induced diabetes. In the present investigation, the serum activities of enzymes known to be reliable toxicity markers were monitored in normal and streptozotocin-diabetic rats to discover whether the use of B. forficata decoction has toxic effects on liver, muscle or pancreas tissue or on renal microcirculation. METHODS: An experimental group of normal and streptozotocin-diabetic rats received an aqueous decoction of fresh B. forficata leaves (150 g/L) by mouth for 33 days while a control group of normal and diabetic rats received water for the same length of time. The serum activity of the toxicity markers lactate dehydrogenase, creatine kinase, amylase, angiotensin-converting enzyme and bilirubin were assayed before receiving B. forficata decoction and on day 19 and 33 of treatment. RESULTS: The toxicity markers in normal and diabetic rats were not altered by the diabetes itself nor by treatment with decoction. Whether or not they received B. forficata decoction the normal rats showed a significant increase in serum amylase activity during the experimental period while there was a tendency for the diabetic rats, both treated and untreated with decoction, to have lower serum amylase activities than the normal rats. CONCLUSIONS: Administration of an aqueous decoction of B. forficata is a potential treatment for diabetes and does not produce toxic effects measurable with the enzyme markers used in our study.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Folhas de Planta / Bauhinia / Diabetes Mellitus Experimental / Amilases / Fitoterapia Limite: Animals Idioma: En Revista: BMC Complement Altern Med Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Folhas de Planta / Bauhinia / Diabetes Mellitus Experimental / Amilases / Fitoterapia Limite: Animals Idioma: En Revista: BMC Complement Altern Med Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido