A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.
J Nat Prod
; 67(5): 899-901, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15165161
Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2alpha-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and beta-sitosteryl-beta-d-galactoside (5). The structure of the new compound 1 was established as 3beta-acetoxy-2alpha-hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase beta lyase activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Triterpenos
/
DNA Polimerase beta
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Melastomataceae
/
Inibidores Enzimáticos
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Liases
País/Região como assunto:
America central
/
Costa rica
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Estados Unidos