Assignment of the relative configuration of spiro[4.5]decanes by 13C, 15N and 17O NMR.
Magn Reson Chem
; 42(6): 524-33, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15137046
The relative configuration of 11 1,4-diazaspiro[4.5]decanes (1a-1j and 1m), 15 1,4-oxazaspiro[4.5]decanes (2a-2o) and 10 1,4-dioxaspiro[4.5]decanes (3a-3n) substituted at the 2-, 6-, 7- or 8-position by a methyl group or using the tert-butyl group as a model for the ananchomeric structure is reported. The relative stereochemistry was analyzed by 1H, 13C, 15N and 17O NMR and all isomers present were characterized spectroscopically. Compounds with a methyl group in the six-membered ring show a chair conformation preference with the methyl group in the equatorial position. Compounds with one or two nitrogens exhibit a tautomeric equilibrium between the imine-diazolidine forms, as demonstrated by IR and 13C NMR.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isótopos de Oxigênio
/
Compostos de Espiro
/
Isótopos de Carbono
/
Espectroscopia de Ressonância Magnética
/
Alcanos
/
Isótopos de Nitrogênio
Tipo de estudo:
Evaluation_studies
Idioma:
En
Revista:
Magn Reson Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Reino Unido