Longitudinal comparison between plasma and seminal HIV-1 viral loads during antiretroviral treatment.
Rev Soc Bras Med Trop
; 36(6): 689-94, 2003.
Article
em En
| MEDLINE
| ID: mdl-15049108
This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naive patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sêmen
/
Infecções por HIV
/
HIV-1
/
Fármacos Anti-HIV
/
Carga Viral
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Rev Soc Bras Med Trop
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil