Toxicogenetic evaluation of metronidazole in the treatment of women infected with Trichomonas vaginalis.
Ann Trop Med Parasitol
; 98(2): 139-47, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-15035724
Samples of peripheral blood were collected once from non-smoking women who were healthy (controls) and twice (immediately before and immediately after 7 days of treatment with metronidazole at 500 mg/day) from non-smoking women infected with Trichomonas vaginalis. Lymphocyte cultures were prepared and used, in toxicogenetic studies, to determine the frequency of sister-chromatid exchange (SCE), the mitotic index (MI), and the replication index (RI) for each sample. MTZ treatment of the infected women led to an increase in the frequency of SCE (P <0.001), a decrease in the MI (P <0.003), and a modification in the kinetics of cell proliferation, with a decrease in the RI (P <0.0006). The differences seen between the results for the controls and those for the infected women, before and after MTZ treatment, may be attributed to the presence of the parasite, to the treatment itself, and/or to variation in the host's response to infection with T. vaginalis.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vaginite por Trichomonas
/
Metronidazol
/
Antitricômonas
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Ann Trop Med Parasitol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Argentina
País de publicação:
Reino Unido