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[Spectral analysis of EEG coherence in Alzheimer's disease]. / Analisis espectral de la coherencia cerebral en la enfermedad de Alzheimer.
Calderón González, P L; Parra Rodríguez, M A; Llibre Rodríguez, J J; Gutiérrez, J V.
Afiliação
  • Calderón González PL; Instituto Nacional de Neurologia y Neurocirugia, La Habana, Cuba. pedrol@informed.sld.cu
Rev Neurol ; 38(5): 422-7, 2004.
Article em Es | MEDLINE | ID: mdl-15029518
INTRODUCTION: In analysis of the electrical activity of the brain, coherence is a measure of the degree of synchrony between two or more regions of the brain with regard to their frequency values over a unit of time. AIMS: To explore the functional alterations caused by Alzheimer's disease (AD), by evaluating the behaviour of coherence over the whole spectrum of EEG frequencies. PATIENTS AND METHODS: We studied a group of 42 patients with AD, according to criteria of the NINCDS ADRDA group. Partial coherence (e.g. between two derivations each time) was calculated within and between hemispheres, during a state of mental rest; the Z statistic was also determined by comparing the coherence values with the standard data for age, sex and functional state of the brain. RESULTS: Significantly low coherence values were obtained for the frontal central regions of the left hemisphere (LH) and for the occipital parietal regions of the right hemisphere (RH) in the delta band. The same localisations were carried out for the theta band, in addition to the centrotemporal and temporal regions of the LH. The highest incoherence values were observed for the alpha and beta bands, more specifically in frontal central and occipital parietal derivations of the RH, and temporal derivations of the LH. CONCLUSIONS: Non activated partial coherence acts as an indicator of the degree of functional disconnection between brain regions in AD. Studying activated coherence in these patients could contribute new elements to our knowledge about the functional disorders observed in this disease.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletroencefalografia / Doença de Alzheimer Limite: Female / Humans / Infant / Male Idioma: Es Revista: Rev Neurol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Cuba País de publicação: Espanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Eletroencefalografia / Doença de Alzheimer Limite: Female / Humans / Infant / Male Idioma: Es Revista: Rev Neurol Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Cuba País de publicação: Espanha