Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense.
J Pharm Pharmacol
; 56(3): 381-7, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-15025864
In traditional medicine Gossypium barbadense L. is used against hypertension. Looking for a scientific basis for this use, the blood-pressure-lowering effect of the decoction of the leaves was confirmed. Fraction II (frII) of the crude extract of G. barbadense showed a dose-dependent hypotensive effect in anaesthetized rats. In hexamethonium-treated rats, the blood-pressure-lowering effect of frII was almost abolished. A small decrease of the blood-pressure-lowering effect was followed by an increase in the blood pressure. Phentolamine antagonized the increase in blood pressure in hexamethoniumtreated rats. High doses of atropine (4 mg/rat) suppressed both depressor and heart effects. In-vitro experiments revealed that atropine did not antagonize the contraction of the ileum of the rat. Tripelennamine in a concentration of 100 microg could not influence the contraction either, whereas 300 microg did. In the guinea-pig ileum 10 microg tripelennamine did not reduce the contraction significantly. In the mechanism of action of frII, acetylcholine receptors could be involved, but not histaminergic or adrenergic receptors. Although it is still not known which compound(s) in G. barbadense is (are) the active substance(s), the results obtained may explain the use of this plant in traditional medicine in Suriname.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Gossypium
/
Hipotensão
Limite:
Animals
País/Região como assunto:
America do sul
/
Caribe ingles
/
Suriname
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Suriname
País de publicação:
Reino Unido